Structure of PDB 4tki Chain C

Receptor sequence
>4tkiC (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCN
KKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIG
GMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVT
LGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYL
ITYQIMRP
3D structure
PDB4tki Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainC
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1081 H1084 C1089 C1092 C129 H132 C137 C140
BS02 33E C H1031 G1032 Y1050 Y1060 F1061 A1062 S1068 Y1071 H79 G80 Y98 Y108 F109 A110 S116 Y119
BS03 33E C F1035 I1039 G1043 H1048 F83 I87 G91 H96
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tki, PDBe:4tki, PDBj:4tki
PDBsum4tki
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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