Structure of PDB 4tkf Chain C

Receptor sequence
>4tkfC (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCN
KKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIG
GMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVT
LGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYL
ITYQIMRP
3D structure
PDB4tkf Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1081 H1084 C1089 C1092 C129 H132 C137 C140
BS02 33C C H1031 F1035 A1038 G1043 F1044 D1045 H1048 I1059 Y1060 Y1071 I1075 H79 F83 A86 G91 F92 D93 H96 I107 Y108 Y119 I123 BindingDB: IC50=31nM
BS03 3AB C H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H79 G80 Y108 F109 A110 K115 S116 Y119 E186
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tkf, PDBe:4tkf, PDBj:4tkf
PDBsum4tkf
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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