Structure of PDB 4tju Chain C

Receptor sequence
>4tjuC (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNK
KLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGG
MFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTL
GKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI
TYQIMRP
3D structure
PDB4tju Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainC
Resolution1.57 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1081 H1084 C1089 C1092 C128 H131 C136 C139
BS02 CNQ C H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 H78 G79 Y107 F108 A109 K114 S115 Y118 I122
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tju, PDBe:4tju, PDBj:4tju
PDBsum4tju
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]