Structure of PDB 4rzt Chain C

Receptor sequence
>4rztC (length=301) Species: 536056 (Escherichia coli DH1) [Search protein sequence]
QSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKA
AVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLTASDQTPLNSI
IFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVDARLRLAGWHKYLTRNQ
IQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITE
SGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQ
GQAVKGNQLLPVSLVKRKTTLAPNTQTASPRALADSLMQLARQVSRLESG
Q
3D structure
PDB4rzt Engineering an allosteric transcription factor to respond to new ligands.
ChainC
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RRY C I79 N125 Y126 P127 L148 D193 I20 N66 Y67 P68 L89 D134
BS02 RRJ C A75 P76 R197 W220 N246 D274 A16 P17 R138 W161 N187 D215
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4rzt, PDBe:4rzt, PDBj:4rzt
PDBsum4rzt
PubMed26689263
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

[Back to BioLiP]