Structure of PDB 4ryd Chain C

Receptor sequence

>4rydC (length=466) Species: 9606 (Homo sapiens)

VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTA

3D structure

• PDB: 4ryd Novel Furin Inhibitors with Potent Anti-infectious Activity.
• Chain: C
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D153 H194
• Catalytic site (residue number reindexed from 1): D45 H86
• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	D154 H194 V231 E236 W254 G255 P256 D264 Y308	D46 H86 V123 E128 W146 G147 P148 D156 Y200
BS02	peptide	C	S253 W254 G255 P256 D258 A292 G294 D306 T367 S368	S145 W146 G147 P148 D150 A184 G186 D198 T259 S260
BS03	CA	C	D115 D162 V205 N208 V210 G212	D7 D54 V97 N100 V102 G104
BS04	CA	C	D258 D301 E331	D150 D193 E223
BS05	CA	C	D174 D179 D181	D66 D71 D73

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4ryd, PDBe:4ryd, PDBj:4ryd
• PDBsum: 4ryd
• PubMed: 25974265
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)