Structure of PDB 4rv8 Chain C

Receptor sequence

>4rv8C (length=326) Species: 5807 (Cryptosporidium parvum)

AMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSA
MDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAI
GVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGN
VVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSV
ASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELI
GDTVYKYYRGMGSVGAMKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMG
YLGSASIEELWKKSSYVEITTDVEIV

3D structure

• PDB: 4rv8 Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.
• Chain: C
• Resolution: 2.053 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	I13	C	A165 N191 G212 M302 G303 E329	A124 N150 G171 M261 G262 E272
BS02	IMP	C	S48 M50 G216 S217 I218 C219 D252 G254 M273 G275 S276 Y299 G301 M302 G303 E329	S49 M51 G175 S176 I177 C178 D211 G213 M232 G234 S235 Y258 G260 M261 G262 E272
BS03	I13	C	P26 S354 G357 Y358	P27 S297 G300 Y301

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006164 purine nucleotide biosynthetic process

External links

• PDB: RCSB:4rv8, PDBe:4rv8, PDBj:4rv8
• PDBsum: 4rv8
• PubMed: 25945705
• UniProt: Q8T6T2|IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase (Gene Name=56k.02)