Structure of PDB 4rje Chain C

Receptor sequence
>4rjeC (length=361) Species: 1377 (Aerococcus viridans) [Search protein sequence]
YNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDRA
WKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIGAHGLAHATKEAG
TARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRDI
LDEAKGDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQRYLTAEGM
SLNNSKQKISPRDIEEIAAHSGLPVFVKGIQHPEDADMAIKAGASGIWVS
NHGARQLYEAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVAKALASGA
DVVALGRPVLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQNVEDLKGL
DLFDNPYGYEY
3D structure
PDB4rje The Ala95-to-Gly substitution in Aerococcus viridans l-lactate oxidase revisited - structural consequences at the catalytic site and effect on reactivity with O2 and other electron acceptors.
ChainC
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S122 Y146 T172 D174 K241 H265
Catalytic site (residue number reindexed from 1) S115 Y139 T165 D167 K228 H252
Enzyme Commision number 1.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FNR C P93 I94 S122 Q144 Y146 T172 K241 H265 R268 D296 S297 G298 R300 G319 R320 P86 I87 S115 Q137 Y139 T165 K228 H252 R255 D283 S284 G285 R287 G306 R307
BS02 PYR C Y40 Y146 R181 L211 H265 R268 Y33 Y139 R174 L202 H252 R255
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4rje, PDBe:4rje, PDBj:4rje
PDBsum4rje
PubMed25423902
UniProtQ44467|LOX_AERVM L-lactate oxidase

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