Structure of PDB 4r09 Chain C

Receptor sequence
>4r09C (length=746) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKKQVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQ
GLQNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE
SLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV
FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLI
NLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSS
TSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSF
NYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNL
STINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPDFEFDPHSNFYHFT
RPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVL
SGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA
GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLD
ILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHI
NDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH
NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHG
NPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL
3D structure
PDB4r09 Toll-like receptor 8 senses degradation products of single-stranded RNA.
ChainC
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 06S C Y291 K314 V315 I341 D343 H373 R375 H469 T471 Y245 K268 V269 I295 D297 H327 R329 H398 T400
BS02 UPT C F265 F320 F346 R375 F467 Y468 H469 F470 F219 F274 F300 R329 F396 Y397 H398 F399
BS03 URI C Y348 Y353 F405 R429 Y302 Y307 F359 R383
BS04 URI C D543 D545 V573 T574 D472 D474 V502 T503
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r09, PDBe:4r09, PDBj:4r09
PDBsum4r09
PubMed25599397
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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