Structure of PDB 4r08 Chain C

Receptor sequence
>4r08C (length=731) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGL
QNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESL
TELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFE
TLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINL
TLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTS
LRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNY
IKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLST
INLGINFIKQIDFKLFQNFSNLEIIYLSENRISPDFEFDPHSNFYHFTRP
LIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSG
TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGV
THHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL
WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHIND
NMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR
ISHLPSGFLSEVSSLKHLDLSSNLLKTIKLSMLELHGNPFECTCDIGDFR
RWMDEHLNVKIPRLVDVICASPGDQRGKSIV
3D structure
PDB4r08 Toll-like receptor 8 senses degradation products of single-stranded RNA.
ChainC
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UCG C K314 V315 I341 D343 R370 H373 R375 H469 F470 T471 R472 P473 L474 K266 V267 I293 D295 R322 H325 R327 H396 F397 T398 R399 P400 L401
BS02 URI C Y348 K350 G351 Y353 V378 F405 R429 Y300 K302 G303 Y305 V330 F357 R381 MOAD: Kd=55uM
BS03 URI C D543 D545 V573 T574 D470 D472 V500 T501 MOAD: Kd=55uM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4r08, PDBe:4r08, PDBj:4r08
PDBsum4r08
PubMed25599397
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

[Back to BioLiP]