Structure of PDB 4qps Chain C

Receptor sequence
>4qpsC (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLSGPDQQ
RDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ
RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKI
ADFGLAKLLPLDKDYYVVSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGSLSRLLELLEEGQRLPAPPACPAEVHELMKL
CWAPSPQDRPSFSALGPQLDMLWSGS
3D structure
PDB4qps Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.
ChainC
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N954 D967
Catalytic site (residue number reindexed from 1) N139 D152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 37Q C L828 G829 F833 V836 Y904 L905 G908 C909 R953 L956 L15 G16 F20 V23 Y89 L90 G93 C94 R138 L141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qps, PDBe:4qps, PDBj:4qps
PDBsum4qps
PubMed25552479
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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