Structure of PDB 4qj1 Chain C

Receptor sequence
>4qj1C (length=345) Species: 5807 (Cryptosporidium parvum) [Search protein sequence]
AMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSA
MDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAI
GVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGN
VVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSV
ASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELI
GDTVYKYYRGMGSVGAMKSNKMVPEGIEGRVKYKGEMEGVVYQLVGGLRS
CMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYS
3D structure
PDB4qj1 Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109
ChainC
Resolution2.415 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N09 C A165 M302 G303 E329 A124 M261 G262 E275 BindingDB: IC50=20nM
BS02 IMP C S48 M50 G216 S217 I218 C219 D252 G275 S276 Y299 G301 M302 G303 E329 G330 S49 M51 G175 S176 I177 C178 D211 G234 S235 Y258 G260 M261 G262 E275 G276
BS03 N09 C S354 G357 Y358 S300 G303 Y304 BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qj1, PDBe:4qj1, PDBj:4qj1
PDBsum4qj1
PubMed
UniProtQ8T6T2|IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase (Gene Name=56k.02)

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