Structure of PDB 4qfy Chain C

Receptor sequence

>4qfyC (length=481) Species: 9606 (Homo sapiens)

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

• PDB: 4qfy Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
• Chain: C
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DGT	C	V156 F157 I325 H376 K377	V44 F45 I207 H258 K259
BS02	DGT	C	R333 R352 K354 K523	R215 R234 K236 K405
BS03	DGT	C	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS04	DGT	C	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337
BS05	DCP	C	R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374	R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256
BS06	DGT	C	V117 N119	V5 N7

External links

• PDB: RCSB:4qfy, PDBe:4qfy, PDBj:4qfy
• PDBsum: 4qfy
• PubMed: 25288794
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)