Structure of PDB 4qfx Chain C

Receptor sequence

>4qfxC (length=481) Species: 9606 (Homo sapiens)

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

• PDB: 4qfx Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
• Chain: C
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DTP	C	V156 F157 I325 R372 H376	V44 F45 I207 R254 H258
BS02	DGT	C	K116 I118 D137 Q142 R145	K4 I6 D25 Q30 R33
BS03	DTP	C	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS04	DGT	C	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337
BS05	DGT	C	L150 R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374 Q375	L38 R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256 Q257
BS06	DTP	C	V117 N119	V5 N7

External links

• PDB: RCSB:4qfx, PDBe:4qfx, PDBj:4qfx
• PDBsum: 4qfx
• PubMed: 25288794
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)