Structure of PDB 4qfs Chain C

Receptor sequence
>4qfsC (length=267) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSK
KQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKP
LVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKL
FITSLEELQIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKF
DVINLAAEKTYNNLDVSVTKALQHRLKCYLHETLEAIINRLVEAEVHRLV
DVVKGIVSLSDILQALV
3D structure
PDB4qfs Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
ChainC
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP C H150 I203 A204 V224 S225 H297 S313 S315 D316 H123 I160 A161 V181 S182 H247 S258 S260 D261
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0031669 cellular response to nutrient levels
GO:0051170 import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031588 nucleotide-activated protein kinase complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qfs, PDBe:4qfs, PDBj:4qfs
PDBsum4qfs
PubMed25066137
UniProtP80385|AAKG1_RAT 5'-AMP-activated protein kinase subunit gamma-1 (Gene Name=Prkag1)

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