Structure of PDB 4pz2 Chain C

Receptor sequence

>4pz2C (length=491) Species: 4577 (Zea mays)

LFDVPEIRFTKLFINGSFVDAVSGRTFDTRDPRTGGVIASVAEADKEDVD
LAVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAG
KHPAVTRAVDVGNAAGSLRYFAGAADKIHGETLKMPGQFQGHTLREPLGV
AGVIIPWNFPSTMFAVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQA
GVPDGVINVVPGFGPTAGAALASHMDVDMVSFTGSTEVGRLIMKASAESN
LKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVYVQ
ERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSYIDHG
KREGATLLTGGRPCAPKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKF
KTVEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVNCYFAMG
SDCPFGGRKMSGFGKDEGMHALDKYLAVKSVVTPLRASPWI

3D structure

• PDB: 4pz2 Role and structural characterization of plant aldehyde dehydrogenases from family 2 and family 7.
• Chain: C
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N184 K207 E283 C317 E417 D494
• Catalytic site (residue number reindexed from 1): N158 K181 E257 C291 E389 D466
• Enzyme Commision number: 1.2.1.3: aldehyde dehydrogenase (NAD(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	C	I180 I181 P182 W183 N184 M189 K207 E210 G240 G244 A245 F258 T259 G260 S261 V264 E283 L284 C317 E417 F419	I154 I155 P156 W157 N158 M163 K181 E184 G214 G218 A219 F232 T233 G234 S235 V238 E257 L258 C291 E389 F391

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004029 aldehyde dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

External links

• PDB: RCSB:4pz2, PDBe:4pz2, PDBj:4pz2
• PDBsum: 4pz2
• PubMed: 25734422
• UniProt: W8SZG1