Structure of PDB 4phc Chain C

Receptor sequence
>4phcC (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
KFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKET
LMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHI
AKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSL
QIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNE
MVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDL
KLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPGSVAAGGR
YDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALKIRTTETQVLVA
SAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVA
IIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ
3D structure
PDB4phc Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
ChainC
Resolution2.844 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS C D130 T132 Q173 R326 L328 Y330 Y331 G381 L382 D78 T80 Q121 R274 L276 Y278 Y279 G319 L320
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006427 histidyl-tRNA aminoacylation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4phc, PDBe:4phc, PDBj:4phc
PDBsum4phc
PubMed25151410
UniProtP12081|HARS1_HUMAN Histidine--tRNA ligase, cytoplasmic (Gene Name=HARS1)

[Back to BioLiP]