Structure of PDB 4p72 Chain C

Receptor sequence
>4p72C (length=235) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
ERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDDYHN
FEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVC
PGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQL
EVRFRPSFFPFTEPSAEVDIQCGWLEVMGCGMVHPNVLRMSNIDPEKFQG
FAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR
3D structure
PDB4p72 The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
ChainC
Resolution2.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H76 H90 R116 Q129 T172 A226
Catalytic site (residue number reindexed from 1) H66 H80 R106 Q119 T162 A202
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NL C L64 E131 F169 F171 T172 G203 C204 A226 G228 L54 E121 F159 F161 T162 G179 C180 A202 G204 PDBbind-CN: -logKd/Ki=4.09,IC50=82uM
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4p72, PDBe:4p72, PDBj:4p72
PDBsum4p72
PubMed24936059
UniProtQ9I0A3|SYFA_PSEAE Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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