Structure of PDB 4p5a Chain C

Receptor sequence
>4p5aC (length=223) Species: 249586 (Streptomyces asoensis) [Search protein sequence]
PRIELRSDITVELVDSSASDLAVVKAARVSTSTRGLIRYLMRSRHGSPFE
HNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREVGAAFYVPDATRLLR
QEGKPGDYRYVGGSTDDHQQVVRSATRAYEVAFEEYQRLLDSGIAREIAR
LVLPVSTYSVLYATCNARALMHFLSLRTHRPDAAYVSHPQREIEMVAEQM
ETAWAKLMPVTHEAFTAFGRVSP
3D structure
PDB4p5a Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP
ChainC
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C H61 E66 T89 N182 R184 H45 E50 T73 N166 R168
BS02 FAD C R86 H87 R88 H188 R193 H204 R70 H71 R72 H172 R177 H188
BS03 5BU C E94 S96 A97 R98 R166 E78 S80 A81 R82 R150
BS04 5BU C R82 H83 R86 Y124 R193 R66 H67 R70 Y108 R177
BS05 FAD C N93 E94 N77 E78
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4p5a, PDBe:4p5a, PDBj:4p5a
PDBsum4p5a
PubMed
UniProtC1IC19

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