Structure of PDB 4o4r Chain C

Receptor sequence
>4o4rC (length=474) Species: 223997 (Murine norovirus 1) [Search protein sequence]
PSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERV
DGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPW
TFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMG
KSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCD
ALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAI
LKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPC
TTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELD
MVKYTMALRRYGLLPTRGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRA
SIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVA
SRVSKEAAQVVPRHRSVLRWVRFG
3D structure
PDB4o4r PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 20V C M219 Y341 L391 R392 R393 Q414 K419 M215 Y337 L382 R383 R384 Q405 K410 MOAD: ic50=0.88uM
BS02 20V C F29 L169 Y341 R392 S410 R413 Q414 F25 L165 Y337 R383 S401 R404 Q405 MOAD: ic50=0.88uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4o4r, PDBe:4o4r, PDBj:4o4r
PDBsum4o4r
PubMed24657439
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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