Structure of PDB 4o1o Chain C

Receptor sequence
>4o1oC (length=671) Species: 9823 (Sus scrofa) [Search protein sequence]
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASNCGDLVAIARRNYDSDLVKFLRLHN
WKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYE
DQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLA
LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDL
QPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGD
ISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPEDRLSSLLAHPFFWSWE
SRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVME
EMNAYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLV
MYVYTKLQNTEYMKHFPKTHN
3D structure
PDB4o1o Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
ChainC
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25L C W56 W58 Q66 N89 N122 F124 E129 Y133 K164 W35 W37 Q45 N68 N101 F103 E108 Y112 K143
BS02 25L C R307 R308 Y310 R353 R285 R286 Y288 R320
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4o1o, PDBe:4o1o, PDBj:4o1o
PDBsum4o1o
PubMed24462203
UniProtA5H025

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