Structure of PDB 4o1m Chain C

Receptor sequence
>4o1mC (length=297) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
FPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQK
SLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGV
DGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSN
SAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALES
DTRTLAWEAGQKYGVRVNAISAGPLKSRAASAFIDYAIDYSYNNAPLRRD
LHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPL
3D structure
PDB4o1m The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y189 K197
Catalytic site (residue number reindexed from 1) Y187 K195
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C G16 G22 Y23 W43 L79 D80 A81 L128 A129 L177 S178 Y179 K197 A224 P226 L227 S229 A231 G14 G20 Y21 W41 L77 D78 A79 L126 A127 L175 S176 Y177 K195 A222 P224 L225 S227 A229
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o1m, PDBe:4o1m, PDBj:4o1m
PDBsum4o1m
PubMed24398298
UniProtQ6UCJ9

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