Structure of PDB 4o0m Chain C

Receptor sequence

>4o0mC (length=490) Species: 197221 (Thermosynechococcus vestitus BP-1) [Search protein sequence]

PTEQSSAEVKKIPTMIEGFDDISHGGLPQGRTTLVSGTSGTGKTLFAVQF
LYNGITIFNEPGIFVTFEESPQDIIKNALSFGWNLQSLIDQGKLFILDAS
PDPDGQEVAGDFDLSALIERIQYAIRKYKATRVSIDSVTAVFQQYDAASV
VRREIFRLAFRLKQLGVTTIMTTERVDEYGPVARFGVEEFVSDNVVILRN
VLEGERRRRTVEILKLRGTTHMKGEYPFTINNGINIFPLGAMRLTQRSSN
VRVSSGVKTLDEMCGGGFFKDSIILATGATGTGKTLLVSKFLETGCQQGE
RALLFAYEESRAQLSRNASSWGIDFEELERRGLLRIICAYPESAGLEDHL
QIIKSEIADFKPSRVAIDSLSALARGVSNNAFRQFVIGVTGFAKQEEITG
FFTNTTDQFMGSNSITESHISTITDTILLLQYVEIRGEMSRAINVFKMRG
SWHDKGIREYVITEKGAEIRDSFRNFEGIISGTPTRISVD

3D structure

PDB

4o0m An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC

Chain

Resolution

2.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	C	K457 M458 R459 S461 W462 H463	K447 M448 R449 S451 W452 H453
BS02	ATP	C	F200 K225 L226 R227 T229 T230 H231	F190 K215 L216 R217 T219 T220 H221
BS03	ATP	C	T290 G291 G293 K294 T295 L296 W331 I472	T280 G281 G283 K284 T285 L286 W321 I462
BS04	ATP	C	G50 T51 K53 T54 L55 S90 F91 I240	G40 T41 K43 T44 L45 S80 F81 I230

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0046777	protein autophosphorylation
GO:0048511	rhythmic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4o0m, PDBe:4o0m, PDBj:4o0m
PDBsum	4o0m
PubMed	24816106
UniProt	Q79V60\|KAIC_THEVB Circadian clock oscillator protein KaiC (Gene Name=kaiC)

[Back to BioLiP]