Structure of PDB 4nst Chain C

Receptor sequence
>4nstC (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEG
FPITAIREIKILRQLIHRSVVNMKEIVTDKGAFYLVFEYMDHDLMGLLES
GLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLA
DFGLARLYNSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILG
ELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQ
YRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSK
MAPPDLPHWQDCHELWSK
3D structure
PDB4nst The structure and substrate specificity of human Cdk12/Cyclin K.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D859 K861 S863 N864 D877 S889 T898
Catalytic site (residue number reindexed from 1) D133 K135 S137 N138 D151 S162 T171
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C I733 G736 T737 A754 K756 Y815 M816 D819 S863 L866 D877 H1040 I17 G20 T21 A38 K40 Y89 M90 D93 S137 L140 D151 H313
BS02 AF3 C D859 K861 D877 D133 K135 D151
BS03 MG C N864 D877 N138 D151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nst, PDBe:4nst, PDBj:4nst
PDBsum4nst
PubMed24662513
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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