Structure of PDB 4nru Chain C

Receptor sequence
>4nruC (length=478) Species: 223997 (Murine norovirus 1) [Search protein sequence]
PRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDE
RVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQK
PWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYE
MGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPF
CDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQR
AILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGC
PCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLE
LDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGW
YGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGE
KYYRTVASRVSKEVVPRHRSVLRWVRFG
3D structure
PDB4nru Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NG C M221 R392 R393 Q414 W417 T418 K419 R436 Q439 M219 R390 R391 Q412 W415 T416 K417 R434 Q437 MOAD: ic50=115nM
BS02 MG C D240 D344 E345 S389 D238 D342 E343 S387
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4nru, PDBe:4nru, PDBj:4nru
PDBsum4nru
PubMed24622391
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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