Structure of PDB 4ng4 Chain C

Receptor sequence

>4ng4C (length=388) Species: 227377 (Coxiella burnetii RSA 493)

PFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQK
ARVMILSHLGRPEEGKFEKEFSLAPVARLLSKKLNVPLINDWLKGVAVEP
GQAILCENVRFNKGENENNTELAKRMAELCDIFVMDAFATAHRAQASTAG
VAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLEN
LLDKVDQLIVGGGIANTFLKAQGYSIGKSLCENEWLDAAQQFWEKAAEKN
VSLPLPVDVIVADELSEDAKATVKNIDAVTSNESIFDVGPNTSATYAKLM
AQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKSTAYSIVGGGDTLAALD
KFNLTDQMSYVSTAGGAFLEFLEGLPAIKILTQRAKEY

3D structure

• PDB: 4ng4 Structural genomics for drug design against the pathogen Coxiella burnetii.
• Chain: C
• Resolution: 2.78 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R39 K196 G349 G372
• Catalytic site (residue number reindexed from 1): R35 K190 G343 G366
• Enzyme Commision number: 2.7.2.3: phosphoglycerate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	C	D293 G319 F326 S327 T330	D287 G313 F320 S321 T324
BS02	ADP	C	G194 K200 G218 L236 I291 N315 P317 G319 E322 D350 T351	G188 K194 G212 L230 I285 N309 P311 G313 E316 D344 T345

Gene Ontology

Molecular Function

• GO:0004618 phosphoglycerate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0043531 ADP binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0016310 phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ng4, PDBe:4ng4, PDBj:4ng4
• PDBsum: 4ng4
• PubMed: 26033498
• UniProt: Q83AU6|PGK_COXBU Phosphoglycerate kinase (Gene Name=pgk)