Structure of PDB 4nb4 Chain C

Receptor sequence
>4nb4C (length=265) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
GMKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCL
TGGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGT
GTSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDR
NTIDLKVRHIYKEPPIPGDLTAANFGHVLHHLDDFTPSNKLAAVIGVVGE
VVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVE
NGAFSGAIGALYLEK
3D structure
PDB4nb4 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C G8 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G9 L12 K14 G99 T100 G122 Q126 Y138 S223 S224
BS02 SH3 C E70 G100 T101 R113 G116 I117 E71 G101 T102 R114 G117 I118
BS03 SH3 C I159 T172 A173 E202 Y240 I160 T171 A172 E200 Y238
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4nb4, PDBe:4nb4, PDBj:4nb4
PDBsum4nb4
PubMed24470271
UniProtQ6G7I0|COAW_STAAS Type II pantothenate kinase (Gene Name=coaW)

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