Structure of PDB 4n1a Chain C

Receptor sequence

>4n1aC (length=554) Species: 471852 (Thermomonospora curvata DSM 43183) [Search protein sequence]

WLPPLDVPPTLDELLPPLSPSAAHGYTADGWEWRGRLHAVVGLVDRPFDQ
RRDPYWLDLSGGAGHVGVAGGPQTGKSTMLRTLITSLALLHTPQEVQFYC
LDFGGGTLAGLAELPHVGSVATRLDADRIRRTVAEVSALLEQREQEFTER
GIDSMATYRRLRATGEYAGDGFGDVFLVVDNWLTLRQDYEALEDSITQLA
ARGLGYGIHVVLSSNKWSEFRTSIRDLLGTKLELRLGDPYESEVDRKKAA
NVPENRPGRGLTRDGYHFLTALPRIDGDTSAETLTEGIATTVKTIREAWH
GPTAPPVRMLPNVLPAAQLPSAAESGTRIPIGIDEDSLSPVYLDFNTDPH
FLVFGDTECGKSNLLRLITAGIIERYTPQQARLIFIDYSRSLLDVATTEH
QIGYAASSTAASSLVRDIKGAMEARLPPPDLTPEQLRSRSWWTGAELFLV
VDDYEMVATSDNPLRPLAELLPQARDIGLHLIIARSMGGAGRALYEPIIQ
RIKEMASPGLVMSGNKDEGILLGNVKPHKLPQGRGYFVERRSGTRLIQTA
YRES

3D structure

PDB

4n1a Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.

Chain

Resolution

3.24 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	R1143 I1163 D1178 T1204	R382 I402 D417 T443
BS02	ATP	C	P769 Q834 G836 K837 S838 T839 T1031	P8 Q73 G75 K76 S77 T78 T270
BS03	ATP	C	E1119 G1121 K1122 S1123 N1124 Q1293 T1310 A1311 Y1312	E358 G360 K361 S362 N363 Q532 T549 A550 Y551
BS04	MG	C	S838 G865 D941	S77 G104 D180
BS05	MG	C	S1123 D1213 D1214	S362 D452 D453

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:4n1a, PDBe:4n1a, PDBj:4n1a
PDBsum	4n1a
PubMed	25865481
UniProt	D1A4G7\|ECCC_THECD ESX secretion system protein EccC (Gene Name=eccC)

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