Structure of PDB 4n07 Chain C

Receptor sequence
>4n07C (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECG
3D structure
PDB4n07 Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
ChainC
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2J9 C K104 P105 F106 M107 S108 K104 P105 F106 M107 S108 MOAD: Kd=0.35uM
BindingDB: EC50=900nM
BS02 2J9 C P105 S108 S217 K218 G219 P105 S108 S217 K218 G219 MOAD: Kd=0.35uM
BindingDB: EC50=900nM
BS03 GLU C Y61 L90 T91 R96 G141 S142 T143 E193 Y61 L90 T91 R96 G141 S142 T143 E193
BS04 ZN C E42 H46 E42 H46
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4n07, PDBe:4n07, PDBj:4n07
PDBsum4n07
PubMed24131202
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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