Structure of PDB 4mmm Chain C

Receptor sequence
>4mmmC (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
SAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSK
THLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLAD
PTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGL
TCSLAPNIISQL
3D structure
PDB4mmm Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5
ChainC
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.24: thioredoxin-dependent peroxiredoxin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BP7 C T44 P45 G46 C47 T45 P46 G47 C48 MOAD: Kd=150uM
Gene Ontology
Molecular Function
GO:0008379 thioredoxin peroxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0034599 cellular response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:4mmm, PDBe:4mmm, PDBj:4mmm
PDBsum4mmm
PubMed25025339
UniProtP30044|PRDX5_HUMAN Peroxiredoxin-5, mitochondrial (Gene Name=PRDX5)

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