Structure of PDB 4mec Chain C

Receptor sequence
>4mecC (length=213) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPA
TQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS
GEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLN
IELFEELQALLTE
3D structure
PDB4mec Distal regulation of heme binding of heme oxygenase-1 mediated by conformational fluctuations
ChainC
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N30 Y58 T135 R136 G139 D140 G144
Catalytic site (residue number reindexed from 1) N20 Y48 T125 R126 G129 D130 G134
Enzyme Commision number 1.14.14.18: heme oxygenase (biliverdin-producing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZNH C K69 Q70 K59 Q60
BS02 ZNH C H25 Q38 G139 F207 H15 Q28 G129 F197
Gene Ontology
Molecular Function
GO:0004392 heme oxygenase (decyclizing) activity
Biological Process
GO:0006788 heme oxidation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mec, PDBe:4mec, PDBj:4mec
PDBsum4mec
PubMed25496210
UniProtP06762|HMOX1_RAT Heme oxygenase 1 (Gene Name=Hmox1)

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