Structure of PDB 4m55 Chain C

Receptor sequence
>4m55C (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHEN
FELINHDVVEPLYIEVDQIYHLASPASYNPIKTLKTNTIGTLNMLGLAKR
VGARLLLASTSEVYEGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHM
NDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVS
SPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLKPDIKKAKLMLGWEPVV
PLEEGLNKAIHYFRKELEYQA
3D structure
PDB4m55 Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.
ChainC
Resolution2.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T202 R272
Catalytic site (residue number reindexed from 1) T110 R154
Enzyme Commision number 4.1.1.35: UDP-glucuronate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C G95 G98 F99 V100 D119 N120 F121 T123 G124 D144 V145 L159 A160 S161 P162 T178 K235 T261 H267 R272 G8 G11 F12 V13 D32 N33 F34 T36 G37 D57 V58 L72 A73 S74 P75 T86 K117 T143 H149 R154
Gene Ontology
Molecular Function
GO:0048040 UDP-glucuronate decarboxylase activity
GO:0070403 NAD+ binding
Biological Process
GO:0042732 D-xylose metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4m55, PDBe:4m55, PDBj:4m55
PDBsum4m55
PubMed25521717
UniProtQ8NBZ7|UXS1_HUMAN UDP-glucuronic acid decarboxylase 1 (Gene Name=UXS1)

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