Structure of PDB 4m1y Chain C

Receptor sequence
>4m1yC (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVSYRKQVVIDGETSLLDILDTA
GRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGN
KSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKH
K
3D structure
PDB4m1y K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
ChainC
Resolution1.491 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP C G13 V14 G15 K16 S17 A18 F28 N116 K117 D119 S145 A146 K147 G13 V14 G15 K16 S17 A18 F28 N100 K101 D103 S129 A130 K131
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m1y, PDBe:4m1y, PDBj:4m1y
PDBsum4m1y
PubMed24256730
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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