Structure of PDB 4lz8 Chain C

Receptor sequence
>4lz8C (length=257) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW
WYDKGEC
3D structure
PDB4lz8 Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
ChainC
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YX C P494 F495 M496 S497 S729 K730 P101 F102 M103 S104 S213 K214
BS02 ZN C E431 H435 E38 H42
BS03 GLU C Y450 T480 R485 L650 G653 S654 T655 E705 Y57 T87 R92 L134 G137 S138 T139 E189
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4lz8, PDBe:4lz8, PDBj:4lz8
PDBsum4lz8
PubMed24215237
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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