Structure of PDB 4loc Chain C

Receptor sequence
>4locC (length=595) Species: 347834 (Rhizobium etli CFN 42) [Search protein sequence]
DRATKLLTYLADVTVNGHPEAKDRPKPLENAARPVVPYGNGVKDGTKQLL
DTLGPKKFGEWMRNEKRVLLTDTTMRDGHQSLLATRMRTYDIARIAGTYS
HALPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLLRG
ANGVGYTNYPDNVVKYFVRQAAKGGIDLFRVFDCLNWVENMRVSMDAIAE
ENKLCEAAICYTGDILNSARPKYDLKYYTNLAVELEKAGAHIIAVKDMAG
LLKPAAAKVLFKALREATGLPIHFHTHDTSGIAAATVLAAVEAGVDAVDA
AMDALSGNTSQPCLGSIVEALSGSERDPGLDPAWIRRISFYWEAVRNQYA
AFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHQVAQAYADAN
QMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPDREVSFPESVVSML
KGDLGQPPSGWPEALQKKALKGEKPYTVRPGSLLKEADLDAERKVIEKKL
EREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLADGEEL
FADIEKGKTLVIVNQAVSATDSQGMVTVFFELNGQPRRIKVPDRA
3D structure
PDB4loc The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase.
ChainC
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D549 D655 K718 H747 H749 T882
Catalytic site (residue number reindexed from 1) D77 D183 K246 H275 H277 T410
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D549 K718 H747 H749 D77 K246 H275 H277
BS02 MG C M534 R535 E537 D768 M62 R63 E65 D296
BS03 BTN C D482 G487 P489 T597 Y1001 R1066 D12 G17 P19 T125 Y529 R594
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4loc, PDBe:4loc, PDBj:4loc
PDBsum4loc
PubMed25157442
UniProtQ2K340

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