Structure of PDB 4lkm Chain C

Receptor sequence
>4lkmC (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANIARLPYLRTWFRTRSAIILHLSNG
SVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELAS
RLRYARTMVDKLLSSR
3D structure
PDB4lkm Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C W414 V415 D416 Y417 Y485 H489 L490 L491 R516 H538 K540 W44 V45 D46 Y47 Y115 H119 L120 L121 R138 H160 K162
External links
PDB RCSB:4lkm, PDBe:4lkm, PDBj:4lkm
PDBsum4lkm
PubMed24223211
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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