Structure of PDB 4lhv Chain C

Receptor sequence
>4lhvC (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
DYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGK
RIKLQIWDTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEK
MILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLA
RDIKAKMDKK
3D structure
PDB4lhv Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
ChainC
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP C S17 G18 V19 G20 K21 T22 C23 F33 N34 N121 K122 D124 S151 A152 K153 S12 G13 V14 G15 K16 T17 C18 F28 N29 N105 K106 D108 S135 A136 K137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4lhv, PDBe:4lhv, PDBj:4lhv
PDBsum4lhv
PubMed24072714
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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