Structure of PDB 4l5r Chain C

Receptor sequence
>4l5rC (length=198) Species: 10090 (Mus musculus) [Search protein sequence]
TPKKNISKGAVLHEKPMTVMVLTATEPFNYKEGKENMFHATVATESKYYR
VKVFNMDLKEKFTENQFITISKYFNSSGILEINETATVSEAAPNQMFEVP
KNIIRSAKETLKISKIKELDSGTLIYGVFAVEKKKVNDKSITFKIKDNED
NIKVVWDKEQHNINYEKGDKLQLFSFHLRKGNGKPILHSGNHSFIKGE
3D structure
PDB4l5r Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
ChainC
Resolution1.873 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C S166 G167 H222 R224 G226 N227 G235 N236 S121 G122 H177 R179 G181 N182 G190 N191 PDBbind-CN: Kd=1.7uM
BS02 dna C K48 K53 K180 N182 D183 K184 S185 T187 K198 K3 K8 K135 N137 D138 K139 S140 T142 K153 PDBbind-CN: Kd=1.7uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0035458 cellular response to interferon-beta

View graph for
Biological Process
External links
PDB RCSB:4l5r, PDBe:4l5r, PDBj:4l5r
PDBsum4l5r
PubMed23850291
UniProtQ9R002|IFI2_MOUSE Interferon-activable protein 202 (Gene Name=Ifi202)

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