Structure of PDB 4l0o Chain C

Receptor sequence

>4l0oC (length=366) Species: 85962 (Helicobacter pylori 26695)

MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGGYEYSRSGNPTRF
ALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFR
LFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL
AQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDV
VAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQ
KNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKN
DSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHAGIRDGLVRLSVGIE
HEQDLLEDLEQAFAKI

3D structure

• PDB: 4l0o Structure determination of cystathionine gamma-synthase from Helicobacter pylori
• Chain: C
• Resolution: 2.76 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R46 Y98 D170 K195
• Catalytic site (residue number reindexed from 1): R43 Y95 D167 K192
• Enzyme Commision number: 2.5.1.48: cystathionine gamma-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	C	Y44 R46	Y41 R43
BS02	PLP	C	S73 G74 L75 Y98 D170 S192 T194 K195	S70 G71 L72 Y95 D167 S189 T191 K192

Gene Ontology

Molecular Function

• GO:0003962 cystathionine gamma-synthase activity
• GO:0004123 cystathionine gamma-lyase activity
• GO:0016740 transferase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009086 methionine biosynthetic process
• GO:0019343 cysteine biosynthetic process via cystathionine
• GO:0019346 transsulfuration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4l0o, PDBe:4l0o, PDBj:4l0o
• PDBsum: 4l0o
• UniProt: P56069|METB_HELPY Cystathionine gamma-synthase (Gene Name=metB)