Structure of PDB 4kq2 Chain C

Receptor sequence

>4kq2C (length=638) Species: 764101 (Saccharomyces cerevisiae FostersO)

SRDLQNHLLFETATEVANRVGGIYSVLKSKAPITVAQYKDHYHLIGPLNK
ATYQNEVDILDWKKPEAFSDEMRPVQHALQTMESRGVHFVYGRWLIEGAP
KVILFDLDSVRGYSNEWKGDLWSLVGIPSPENDFETNDAILLGYTVAWFL
GEVAHLDSQHAIVAHFHEWLAGVALPLCRKRRIDVVTIFTTHATLLGRYL
CASGSFDFYNCLESVDVDHEAGRFGIYHRYCIERAAAHSADVFTTVSQIT
AFEAEHLLKRKPDGILPNGLNVIKFQAFHEFQNLHALKKEKINDFVRGHF
HGCFDFDLDNTLYFFIAGRYEYKNKGADMFIEALARLNYRLKVSGSKKTV
VAFIVMPAKNNSFTVEALKGQAEVRALENTVHEVTTSIGKRIFDHAIRYP
HNGLTTELPTDLGELLKSSDKVMLKRRILALRRPEGQLPPIVTHNMVDDA
NDLILNKIRQVQLFNSPSDRVKMIFHPEFLNANNPILGLDYDEFVRGCHL
GVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGSYMEDLIETNQAKDYGI
YIVDRRFKAPDESVEQLVDYMEEFVKKTRRQRINQRNATEALSDLLDWKR
MGLEYVKARQLALRRGYPDQFRELVGEELNDSNMDALA

3D structure

• PDB: 4kq2 Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.
• Chain: C
• Resolution: 2.95 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.11: glycogen(starch) synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1S3	C	G23 H193 R199 R320 E509 P510 W511 G512	G22 H192 R198 R319 E508 P509 W510 G511
BS02	U5P	C	R20 K326 F480 Y492 T514 E517	R19 K325 F479 Y491 T513 E516
BS03	G6P	C	Q283 H286 A287 K290 H500 R580 R583 R587	Q282 H285 A286 K289 H499 R579 R582 R586

Gene Ontology

Molecular Function

• GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
• GO:0005515 protein binding
• GO:0016757 glycosyltransferase activity
• GO:0042802 identical protein binding
• GO:2001069 glycogen binding

Biological Process

• GO:0005978 glycogen biosynthetic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0042587 glycogen granule

External links

• PDB: RCSB:4kq2, PDBe:4kq2, PDBj:4kq2
• PDBsum: 4kq2
• PubMed: 24324135
• UniProt: P27472|GYS2_YEAST Glycogen [starch] synthase isoform 2 (Gene Name=GSY2)