Structure of PDB 4kpe Chain C

Receptor sequence
>4kpeC (length=208) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKG
LGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKW
IEDNVKFT
3D structure
PDB4kpe Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
ChainC
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C E433 G457 E19 G43
BS02 dna C K458 I460 N461 K464 H513 V626 R629 R630 K44 I46 N47 K50 H99 V194 R197 R198
BS03 dna C G434 D435 S436 R456 G20 D21 S22 R42
BS04 MG C D506 D508 D92 D94
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4kpe, PDBe:4kpe, PDBj:4kpe
PDBsum4kpe
PubMed27655731
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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