Structure of PDB 4kn2 Chain C

Receptor sequence
>4kn2C (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
TDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSR
LYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFL
DVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFES
YFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYA
A
3D structure
PDB4kn2 Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYA C Y76 F78 D97 Y101 W118 W150 H151 R152 G153 W154 W156 W187 Y52 F54 D73 Y77 W94 W126 H127 R128 G129 W130 W132 W163 BindingDB: IC50=60nM
External links
PDB RCSB:4kn2, PDBe:4kn2, PDBj:4kn2
PDBsum4kn2
PubMed23934049
UniProtP14207|FOLR2_HUMAN Folate receptor beta (Gene Name=FOLR2)

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