Structure of PDB 4kba Chain C

Receptor sequence
>4kbaC (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIY
KMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVL
LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY
YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGL
KAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDY
SYLRQLFRNLFHRQGFSYDYVFDWNML
3D structure
PDB4kba Ligand-protein interactions of selective casein kinase 1 delta inhibitors.
ChainC
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D122 K124
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1QM C I15 I23 A36 M80 M82 L85 G86 L135 I148 I9 I17 A30 M74 M76 L79 G80 L129 I142 MOAD: ic50=6nM
BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4kba, PDBe:4kba, PDBj:4kba
PDBsum4kba
PubMed23919824
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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