Structure of PDB 4jx5 Chain C

Receptor sequence
>4jx5C (length=591) Species: 347834 (Rhizobium etli CFN 42) [Search protein sequence]
DRATKLLTYLADVTVNGHPEAKDRPKPLENRPVVPYGNGVKDGTKQLLDT
LGPKKFGEWMRNEKRVLLTDTTMRDGHQSLLATRMRTYDIARIAGTYSHA
LPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLLRGAN
GVGYTNYPDNVVKYFVRQAAKGGIDLFRVFDCLNWVENMRVSMDAIAEEN
KLCEAAICYTGDILNSARPKYDLKYYTNLAVELEKAGAHIIAVKDMAGLL
KPAAAKVLFKALREATGLPIHFHTHDTSGIAAATVLAAVEAGVDAVDAAM
DALSGNTSQPCLGSIVEALSGSERDPGLDPAWIRRISFYWEAVRNQYAAF
ESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHQVAQAYADANQM
FGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPDREFPESVVSMLKGDL
GQPPSGWPEALQKKALKGEKPYTVRPGSLLKEADLDAERKVIEKKLEREV
SDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLADGEELFADI
EKGKTLVIVNQAVSATDSQGMVTVFFELNGQPRRIKVPDRA
3D structure
PDB4jx5 A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase.
ChainC
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D549 D655 K718 H747 H749 T882
Catalytic site (residue number reindexed from 1) D75 D181 K244 H273 H275 T408
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C M534 R535 E537 D768 M60 R61 E63 D294
BS02 ZN C D549 K718 H747 H749 D75 K244 H273 H275
BS03 PYR C R548 Q552 L619 R621 K718 T882 R74 Q78 L145 R147 K244 T408
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:4jx5, PDBe:4jx5, PDBj:4jx5
PDBsum4jx5
PubMed23698000
UniProtQ2K340

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