Structure of PDB 4je5 Chain C

Receptor sequence
>4je5C (length=492) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TLPESKDFSYLFSDETNARKPSPLKTCPNIIFLGGGLPLKDYFPWDNLSV
DSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGF
SAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGD
VILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAP
KPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMN
PYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVL
APGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGY
LDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDAS
VHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAE
SKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGIS
3D structure
PDB4je5 Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase.
ChainC
Resolution1.909 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
2.6.1.57: aromatic-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP C N141 T142 F166 I215 N220 D248 Y251 S302 S304 K305 N134 T135 F159 I208 N213 D241 Y244 S295 S297 K298
BS02 EPE C F166 R470 F159 R463
BS03 EPE C L170 E174 W443 K445 L163 E167 W436 K438
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0008793 aromatic-amino-acid transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
GO:0080130 L-phenylalanine-2-oxoglutarate transaminase activity
Biological Process
GO:0006571 tyrosine biosynthetic process
GO:0009058 biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009074 aromatic amino acid family catabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019509 L-methionine salvage from methylthioadenosine
GO:0019878 lysine biosynthetic process via aminoadipic acid
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4je5, PDBe:4je5, PDBj:4je5
PDBsum4je5
PubMed23893908
UniProtP53090|ARO8_YEAST Aromatic/aminoadipate aminotransferase 1 (Gene Name=ARO8)

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