Structure of PDB 4iqj Chain C

Receptor sequence
>4iqjC (length=1166) Species: 271 (Thermus aquaticus) [Search protein sequence]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRGYFHLTLLAKDFTGYQNLVRL
ASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRLDLA
EARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVATND
GHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRAMLP
EAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLPEGRTEAQYLRE
LTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKEW
TAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGSAA
GSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRVIQ
YVRERYGEDKVAQIGTFASKAALKDVARVYGIPHKKAEELAKLIPVQFGK
PKPLQEAVVPELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVIAA
EPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEARR
IVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRGLK
PRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLRPI
LDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHRER
FVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYVKA
HYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFKVV
GEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVNKR
ALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVGVEEPPL
VEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEELSEFVR
ELPGKPKVLLSGMVEEVRFTLSDETGALEVVVFGRAYEGVSPKLKEDIPL
LVLAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGVARLKSLLDE
HPGSLPVYLRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREV
FLQGNGGGPKEEVVPF
3D structure
PDB4iqj Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C E302 R304 E290 R292
BS02 ZN C E72 H95 C145 E68 H83 C133
BS03 ZN C D20 H47 H214 D16 H43 H202
BS04 ZN C H11 H13 E72 D212 H7 H9 E68 D200
BS05 MG C D463 D465 D618 D435 D437 D585
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqj, PDBe:4iqj, PDBj:4iqj
PDBsum4iqj
PubMed23478062
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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