Structure of PDB 4imy Chain C

Receptor sequence
>4imyC (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
VECPFCDEVSKYEKLAKIGGEVFKARHRKTGQKVALKKVLMENEKEGFPI
TALREIKILQLLKHENVVNLIEICRTKGSIYLVFDFCEHDLAGLLSNVLV
KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG
LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM
AEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVK
GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP
MPSDLKGMLST
3D structure
PDB4imy The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
ChainC
Resolution2.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 S180 T191
Catalytic site (residue number reindexed from 1) D130 K132 A134 N135 D148 S161 T172
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP C A46 K48 F103 D104 C106 D167 A35 K37 F84 D85 C87 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4imy, PDBe:4imy, PDBj:4imy
PDBsum4imy
PubMed23471103
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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