Structure of PDB 4ien Chain C

Receptor sequence

>4ienC (length=154) Species: 272831 (Neisseria meningitidis FAM18)

RQLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYC
VTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIRVEAQNIRTGEI
RHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQASE
DMSC

3D structure

• PDB: 4ien Expression, purification and crystallization of acetyl-CoA hydrolase from Neisseria meningitidis.
• Chain: C
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.1.2.20: acyl-CoA hydrolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	C	V55 T56 L57 G84 R85 T86 S87 R146 S149 L150	V51 T52 L53 G80 R81 T82 S83 R142 S145 L146
BS02	GDP	C	E11 Y77 A78 A79 N81 G91 I92 R93 S109 Y111 R138	E7 Y73 A74 A75 N77 G87 I88 R89 S105 Y107 R134
BS03	COA	C	G31 L34 F64 K65 E66 P67	G27 L30 F60 K61 E62 P63
BS04	GDP	C	D155 S157 C158	D151 S153 C154

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0016790 thiolester hydrolase activity

External links

• PDB: RCSB:4ien, PDBe:4ien, PDBj:4ien
• PDBsum: 4ien
• PubMed: 24192375
• UniProt: A1KUS8