Structure of PDB 4i7d Chain C

Receptor sequence
>4i7dC (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
NSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSL
DAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFML
VLEKQEKGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSI
HEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4i7d Structure-based design of covalent siah inhibitors.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C C130 L158 D162 I163 V164 F165 L166 T168 V176 D177 W178 M180 E194 C39 L67 D71 I72 V73 F74 L75 T77 V85 D86 W87 M89 E103
BS02 ZN C C128 C135 H147 H152 C37 C44 H56 H61
BS03 ZN C C98 C105 H117 C121 C7 C14 H26 C30
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4i7d, PDBe:4i7d, PDBj:4i7d
PDBsum4i7d
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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