Structure of PDB 4i7b Chain C

Receptor sequence
>4i7bC (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
VLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDA
VMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVL
EKQEDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHE
GIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4i7b Structure-based design of covalent siah inhibitors.
ChainC
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C T156 L158 D162 I163 V164 F165 L166 T168 V176 D177 W178 V179 M180 N276 T63 L65 D69 I70 V71 F72 L73 T75 V83 D84 W85 V86 M87 N181
BS02 ZN C C128 C135 H147 H152 C35 C42 H54 H59
BS03 ZN C C98 C105 H117 C121 C5 C12 H24 C28
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4i7b, PDBe:4i7b, PDBj:4i7b
PDBsum4i7b
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

[Back to BioLiP]