Structure of PDB 4hso Chain C

Receptor sequence
>4hsoC (length=346) Species: 122586 (Neisseria meningitidis MC58) [Search protein sequence]
YPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDK
RLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTV
GWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQY
YADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGA
ASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQ
LRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVE
SHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA
3D structure
PDB4hso Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR C Q153 L177 S182 Q149 L173 S178 MOAD: Kd=22uM
BS02 PEP C R94 A166 K188 R236 H270 R90 A162 K184 R232 H266
BS03 MN C C63 H270 E304 D324 C59 H266 E300 D320
BS04 TYR C D8 D9 D4 D5 MOAD: Kd=22uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hso, PDBe:4hso, PDBj:4hso
PDBsum4hso
PubMed23754471
UniProtQ9K169

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